Season 4, Episode 18
Dr. Marc Bubbs interviews scientist and insulin expert Dr. Ben Bikman, PhD to discuss how chronically high insulin levels can drive chronic disease states.
Summary of Episode
3:05 – Why did we get sick 100 years ago compared to today?
5:45 – Why insulin resistance is at the root of most chronic conditions
7:45 – Hyper-insulinemia and weight gain
10:40 – The insulin resistance and heart disease connection (and why it matters)
14:20 – How chronically high blood glucose levels impair your vascular health
16:50 – Football lineman, metabolic profiles and the role of fitness and exercise
23:40 – Taking insulin and how it impacts your fat cells (in diabetics)
28:20 – Why insulin as a medication for type-2 diabetes is a short-sighted approach
32:05 – The connection between insulin resistance and brain function
38:04 – Is there an application for exogenous ketones to prevent (or delay) dementia
39:05 – Dietary strategies to support insulin resistance
46:45 – Blood tests for assessing the degree of insulin resistance
49:05 – Exercise and insulin sensitivity: resistance and aerobic activity
About Dr. Ben Bikman, PhD
Ben Bikman, Ph.D. is a professor of pathophysiology and biomedical scientist whose research agenda focuses on the molecular mediators of obesity and its co-morbidities. Employing cell-autonomous to whole-body systems, his lab’s main efforts explore the intimate associations between the metabolic and immune systems. Most recently his most recent work has focused on scrutinizing the role of ketones as metabolic signaling molecules.
Research Papers & Book
Improvement in Glycemic and Lipid Profiles in Type 2 Diabetics with a 90-Day Ketogenic Diet
Insulin selectively reduces mitochondrial uncoupling in brown adipose tissue in mice
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