Obesity

S4E18: Why We Get Sick: Hyper-Insulinemia & Chronic Disease w/ Dr. Ben Bikman, PhD

Season 4, Episode 18

Dr. Marc Bubbs interviews scientist and insulin expert Dr. Ben Bikman, PhD to discuss how chronically high insulin levels can drive chronic disease states.

Summary of Episode

3:05 – Why did we get sick 100 years ago compared to today?

5:45 – Why insulin resistance is at the root of most chronic conditions

7:45 – Hyper-insulinemia and weight gain

10:40 – The insulin resistance and heart disease connection (and why it matters)

14:20 – How chronically high blood glucose levels impair your vascular health

16:50 – Football lineman, metabolic profiles and the role of fitness and exercise

23:40 – Taking insulin and how it impacts your fat cells (in diabetics)

28:20 – Why insulin as a medication for type-2 diabetes is a short-sighted approach

32:05 – The connection between insulin resistance and brain function

38:04 – Is there an application for exogenous ketones to prevent (or delay) dementia

39:05 – Dietary strategies to support insulin resistance

46:45 – Blood tests for assessing the degree of insulin resistance

49:05 – Exercise and insulin sensitivity: resistance and aerobic activity

 

About Dr. Ben Bikman, PhD  

Ben Bikman, Ph.D. is a professor of pathophysiology and biomedical scientist whose research agenda focuses on the molecular mediators of obesity and its co-morbidities. Employing cell-autonomous to whole-body systems, his lab’s main efforts explore the intimate associations between the metabolic and immune systems. Most recently his most recent work has focused on scrutinizing the role of ketones as metabolic signaling molecules. 

@BenBikmanPhD

The Bikman Lab

GetHlth.com

  

Research Papers & Book

Why We Get Sick

Improvement in Glycemic and Lipid Profiles in Type 2 Diabetics with a 90-Day Ketogenic Diet

Insulin selectively reduces mitochondrial uncoupling in brown adipose tissue in mice


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S4E15: Nutrient-Exercise Timing & Fasted Exercise w/ Dr. Rob Edinburgh, PhD

Season 4, Episode 15

Marc interviews expert physiologist Rob Edinburgh, PhD whose area of interest includes meal timing and exercise.

SUMMARY OF EPISODE

In Season 4, Episode 15 Dr. Marc Bubbs interviews expert physiologist Dr. Rob Edinburgh, PhD whose area of interest includes meal timing and exercise to discuss…

3:00 – Rob’s background in nutrition and research

5:15 – Review of energy balance: energy intake and expenditure

6:10 – What is metabolic health?

13:15 – Effects of skipping breakfast (versus eating breakfast) on exercise adaptations

17:30 – Energy balance over a 24-hour period in breakfast vs. skipping breakfast

21:30 – How does intensity training impact the results of the study?

23:30 –How does ‘breakfast timing’ impact exercise adaptations in overweight and obese individuals

28:30 – Meal + exercise interactions - acute responses to exercise

31:40 – Metabolic benefits of exercising in the fasted-state (in healthy people)

36:30 – The main pathways via which exercise supports better health: AMPK, PGC1-alpha

42:30 – Energy Balance: weight loss and health vs. performance

45:45 – The use of intra-muscular triglyceride during fasted exercise

50:00 – How context is key when it comes to breakfast vs. ‘no breakfast’

53:00 – The evolution of research in this area

About Dr. Rob Edinburgh, PhD  

Rob graduated from the University of Bath in 2015 with a first class honours in Sport and Exercise Science (BSc), winning the David Wilkinson prize for the best physiology student. Rob is particularly interested in how exercise and nutrition can counteract the increasing worldwide prevalence of diseases such as obesity and type 2 diabetes. Rob has also worked at the PEAK Centre for Human Performance in Ottawa (Canada) as an Exercise Physiologist, where he led individualized consultations on exercise and diet, performed exercise tests and ran strength and conditioning classes. 

Twitter @R_Edinburgh93

 

Research Papers

Lipid Metabolism Links Nutrient-Exercise Timing to Insulin Sensitivity in Men Classified as Overweight or Obese

Skipping Breakfast Before Exercise Creates a More Negative 24-hour Energy Balance: A Randomized Controlled Trial in Healthy Physically Active Young Men

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